A window, not a switch
In mice, psilocybin increased connections between neurons in the frontal cortex within a day, and the change lasted at least a month [1]. A separate study found that psilocybin reopened a period of heightened social learning in mice that stayed open for about two weeks [2].
In people, a large clinical trial found that a single 25 mg dose of psilocybin improved treatment-resistant depression at three weeks, while the results for sustained response at twelve weeks were less clear [3]. The benefit is real, and holding onto it is the hard part.
What integration often looks like today
After a session, most clients have a handful of integration conversations with their facilitator or therapist. Those conversations matter. But in between them there is often little structure, and no objective way to see whether the change is holding.
How Psio adds structure
- Measure. A comfortable EEG headband records brain activity before, during, and after the session, giving each person a personal starting point.
- Personalize. Psio turns those recordings into a training program built for that person and that session.
- Train at home. About twelve minutes a day of guided neurofeedback with the headband and the Psio app, during the weeks when change is easiest to keep.
- Track change. The client and their care team see progress over time and use it to guide what comes next.
For facilitators and service centers
Psio fits inside the care you already provide. Your facilitators stay at the center of the work, and Psio adds a measured program around each session: a baseline during preparation, a recording around the session, and a daily practice for the weeks that follow. Clients see their own brain change, and your practice keeps the relationship well beyond the last dose.
